Egyptian Journal of Bronchology

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 12  |  Issue : 2  |  Page : 154--159

Bronchial asthma: clinical phenotypes and endotypes and their relation with glucocorticoids circadian rhythm and parasympathetic activity


Magdy M Zedan1, Magdy Abd El Moneim El-Ziny2, Abd Elazeez Atallah Shabaan2, Youssef M Mosaad3, Wafaa Nabil Laimon4 
1 Professor of Allergy, Respiratory and Clinical Immunology Department, Mansoura University, Faculty of Medicine, Mansoura, Egypt
2 Professor of Pediatrics, Mansoura University, Faculty of Medicine, Mansoura, Egypt
3 Professor of Clinical Pathology, Mansoura University, Faculty of Medicine, Mansoura, Egypt
4 Lecturer of Pediatrics, Mansoura University, Faculty of Medicine, Mansoura, Egypt

Correspondence Address:
Wafaa Nabil Laimon
MD degree in Pediatrics, Lecturer of Pediatrics, Mansoura University Children’s Hospital, Al-Gomhoria Street, Mansoura, 35516
Egypt

Introduction Asthma is a heterogeneous disease and presents in different clinical patterns ‘phenotypes’ as a result of diverse pathobiological background ‘endotypes’. Objectives The aim of this study was to study serum interleukin-13 (IL-13) levels and the frequency of (IL-13) +1923C/T gene polymorphism in Egyptian children with asthma and to study glucocorticoids circadian rhythm in nocturnal asthma. Patients and methods The frequency of (IL-13) +1923C/T gene polymorphism genotypes was determined in 114 asthmatic Egyptian children and compared with a matched group of 152 healthy controls using PCR. Serum IL-13 and cortisol a.m. and p.m. concentrations in serum were assessed using enzyme linked immunosorbent assay. Results Serum IL-13 was found to be significantly higher in asthmatic patients when compared with the control group (P<0.0001). In the asthmatic group, forced expiratory volume in 1 s showed a significant negative correlation with serum IL-13 (ρ=−0.2, P=0.03), whereas peripheral blood eosinophilic % showed a significant positive correlation with serum IL-13 (ρ=0.18, P=0.05). No statistically significant differences were found between asthmatic patients and controls in IL-13 C1923T genotype frequency. A significantly lower serum cortisol pm was found in asthmatic patients with nocturnal symptoms when compared with those without nocturnal symptoms (P<0.0001). Conclusion Serum IL-13 is significantly higher in asthmatic patients when compared with controls. (IL-13) +1923C/T gene polymorphism is not a risk factor for development of asthma in Egyptian children. Nocturnal symptoms in some asthmatic patients can be partly attributed to lower serum cortisol level at night.


How to cite this article:
Zedan MM, El-Ziny MM, Shabaan AA, Mosaad YM, Laimon WN. Bronchial asthma: clinical phenotypes and endotypes and their relation with glucocorticoids circadian rhythm and parasympathetic activity.Egypt J Bronchol 2018;12:154-159


How to cite this URL:
Zedan MM, El-Ziny MM, Shabaan AA, Mosaad YM, Laimon WN. Bronchial asthma: clinical phenotypes and endotypes and their relation with glucocorticoids circadian rhythm and parasympathetic activity. Egypt J Bronchol [serial online] 2018 [cited 2018 Aug 21 ];12:154-159
Available from: http://www.ejbronchology.eg.net/article.asp?issn=1687-8426;year=2018;volume=12;issue=2;spage=154;epage=159;aulast=Zedan;type=0