Year : 2015 | Volume
: 9 | Issue : 3 | Page : 283--286
A study of CA-125 in patients with pleural effusion
Alaa El Din O Shalaby1, Heba Allah A Moussa1, Aml S Nasr2, Mostafa N Abdel Samad1
1 Department of Chest Diseases, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
Background: A significant concern of physicians treating patients with pleural effusion is to rule out a malignant etiology, which, in the majority of series, is the first cause of pleural exudates. Determination of tumor markers in serum and pleural fluid has been proposed as a nonaggressive means of establishing a diagnosis of pleural malignancy. Cancer antigen 125 (CA-125) is not a specific tumor marker and it is synthesized by normal and malignant cells of different origins. Recently, it has been shown that various diseases are associated with increased CA-125 levels, especially in the presence of serosal fluid.
Aim: The aim of this study was to determine the level of serum and pleural fluid CA-125 to evaluate its value as a marker for differentiation between different types of pleural effusion.
Patients and methods: The study was carried out on 30 patients with pleural effusion of different etiologies. They were further subdivided into two groups: exudates and transudates; the levels of both serum and pleural fluid CA-125 were evaluated.
Results: In terms of pleural CA-125, there was a statistically significant increase in the exudative subgroup compared with transudative subgroup. Furthermore, it was found that malignant effusion was observed more frequently compared with benign effusion and tuberculosis was observed more frequently in comparison with other infections.
Conclusion: The highest level of pleural fluid CA-125 was found in malignancy, followed by tuberculosis, and so pleural fluid CA-125 can be used as a marker for the diagnosis of pleural effusion.
Heba Allah A Moussa
Department of Chest Disease, Faculty of Medicine, Cairo University, 10 B Street 199 Degla, Maadi, 11559, Cairo
|How to cite this article:|
Shalaby AO, Moussa HA, Nasr AS, Abdel Samad MN. A study of CA-125 in patients with pleural effusion.Egypt J Bronchol 2015;9:283-286
|How to cite this URL:|
Shalaby AO, Moussa HA, Nasr AS, Abdel Samad MN. A study of CA-125 in patients with pleural effusion. Egypt J Bronchol [serial online] 2015 [cited 2019 Dec 14 ];9:283-286
Available from: http://www.ejbronchology.eg.net/article.asp?issn=1687-8426;year=2015;volume=9;issue=3;spage=283;epage=286;aulast=Shalaby;type=0