Egyptian Journal of Bronchology

: 2014  |  Volume : 8  |  Issue : 1  |  Page : 1--9

Early detection of malignant pleural mesothelioma

Hussein F Mahmoud 
 Female Department, No 6, Abbassia Chest Hospital, Cairo, Egypt

Correspondence Address:
Hussein F Mahmoud
13B Gesr El-Suez St., Manshiet El-Bakry, 3425248-177 Cairo

Malignant pleural mesothelioma (MPM) is a rare tumour. Exposure to asbestos is a well-established aetiological factor for MPM. Patients typically present with shortness of breath due to pleural effusion or chest pain in a more advanced stage. The diagnosis is usually suggested by imaging studies (unilateral pleural thickening; pleural effusion). An occupational history must be obtained. Cytological examination of the effusion can be diagnostic, but often shows equivocal results. Therefore, histology, including immunohistochemistry, is the gold standard. Thoracoscopy, a video-assisted surgical procedure or open pleural biopsy in a fused pleural space may be necessary to provide sufficient material for accurate histological diagnosis. There are three main histological types (epithelial, sarcomatous and mixed) with ∼60% being epithelial. Data suggest the possible contribution of serum mesothelin-related proteins and osteopontin along with others as useful markers to support the diagnosis of mesothelioma; however, the precise role of these markers is yet to be defined.

How to cite this article:
Mahmoud HF. Early detection of malignant pleural mesothelioma.Egypt J Bronchol 2014;8:1-9

How to cite this URL:
Mahmoud HF. Early detection of malignant pleural mesothelioma. Egypt J Bronchol [serial online] 2014 [cited 2020 Nov 25 ];8:1-9
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