Year : 2014 | Volume
: 8 | Issue : 1 | Page : 1--9
Early detection of malignant pleural mesothelioma
Hussein F Mahmoud
Female Department, No 6, Abbassia Chest Hospital, Cairo, Egypt
Malignant pleural mesothelioma (MPM) is a rare tumour. Exposure to asbestos is a well-established aetiological factor for MPM. Patients typically present with shortness of breath due to pleural effusion or chest pain in a more advanced stage. The diagnosis is usually suggested by imaging studies (unilateral pleural thickening; pleural effusion). An occupational history must be obtained. Cytological examination of the effusion can be diagnostic, but often shows equivocal results. Therefore, histology, including immunohistochemistry, is the gold standard. Thoracoscopy, a video-assisted surgical procedure or open pleural biopsy in a fused pleural space may be necessary to provide sufficient material for accurate histological diagnosis. There are three main histological types (epithelial, sarcomatous and mixed) with ∼60% being epithelial.
Data suggest the possible contribution of serum mesothelin-related proteins and osteopontin along with others as useful markers to support the diagnosis of mesothelioma; however, the precise role of these markers is yet to be defined.
Hussein F Mahmoud
13B Gesr El-Suez St., Manshiet El-Bakry, 3425248-177 Cairo
|How to cite this article:|
Mahmoud HF. Early detection of malignant pleural mesothelioma.Egypt J Bronchol 2014;8:1-9
|How to cite this URL:|
Mahmoud HF. Early detection of malignant pleural mesothelioma. Egypt J Bronchol [serial online] 2014 [cited 2020 Aug 8 ];8:1-9
Available from: http://www.ejbronchology.eg.net/article.asp?issn=1687-8426;year=2014;volume=8;issue=1;spage=1;epage=9;aulast=Mahmoud;type=0