|Year : 2019 | Volume
| Issue : 5 | Page : 654-659
Effectiveness of APACHE II and SAPS II scoring models in foreseeing the outcome of critically ill COPD patients
Yousef Ahmed, Mohamed Adam, Lamees M Bakkar
Chest Department, Faculty of Medicine, Assiut University, Assiut, Egypt
|Date of Submission||23-Aug-2019|
|Date of Acceptance||24-Nov-2019|
|Date of Web Publication||21-Jan-2020|
MD Yousef Ahmed
Chest Department, Faculty of Medicine, Assiut University Hospital, Assiut, 71515
Source of Support: None, Conflict of Interest: None
Background Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) scoring systems are the two models that are greatly used by the majority of ICUs to predict clinical consequence.
Objective The aim of the study was to assess the performance of APACHE II and SAPS II scoring methods in foreseeing death among critically ill chronic obstructive pulmonary disease (COPD) patients.
Materials and methods This prospective research included 104 COPD patients who were admitted to the respiratory intensive care unit (RICU) at Assiut University Hospital. The patients were classified as survivors and nonsurvivors. Each scoring system was assessed for its discrimination, calibration, and overall performance.
Results On the basis of the outcome of the study population, 36 (34.6%) patients were non-survivors while 68 (65.4%) patients were survivors. Both APACHE II and SAPS II scores were significantly higher in nonsurvivors. The discriminative power of both models was good as determined by the receiver operating characteristic curve. At a cutoff point greater than 20 for APACHE II and greater than 48 for SAPS II, survival or death can be predicted. The Lemeshow–Hosmer goodness-of-fit C statistics showed good performance and good calibration for both models. APACHE II score had the least Brier score and reliability but had the highest resolution.
Conclusion The conclusions made were first, APACHE II and SAPS II have nearly similar performance in predicting mortality among COPD patients but with some preference for APACHE. Second, Both models have good discrimination and good calibration.
Keywords: Acute Physiology and Chronic Health Evaluation II, Assiut, chronic obstructive pulmonary disease, respiratory intensive care unit, Simplified Acute Physiology Score II
|How to cite this article:|
Ahmed Y, Adam M, Bakkar LM. Effectiveness of APACHE II and SAPS II scoring models in foreseeing the outcome of critically ill COPD patients. Egypt J Bronchol 2019;13, Suppl S1:654-9
|How to cite this URL:|
Ahmed Y, Adam M, Bakkar LM. Effectiveness of APACHE II and SAPS II scoring models in foreseeing the outcome of critically ill COPD patients. Egypt J Bronchol [serial online] 2019 [cited 2020 Jul 15];13, Suppl S1:654-9. Available from: http://www.ejbronchology.eg.net/text.asp?2019/13/5/654/276303
| Introduction|| |
Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating airway disease that results in a large burden, both medically and financially. It affects millions of people around the world and causes great rates of morbidity and mortality. This burden is anticipated to increase with an estimated 5.8 million deaths annually by 2030 . A large proportion of patients with COPD usually require admission to the ICU and it may be helpful to recognize patients at the time of admission who are probable to have bad consequence, so that these patients can be managed violently . There are many ICU scoring models, and numerous new systems are being progressed to assess severity of illness in ICU patients. The use of scoring models particularly developed for patient evaluation at the time of ICU entry has decreased many troubles and helped therapy delineation. Furthermore, these methods aid in assessing and comparing the goodness and magnitude of care between different health-care academies ,. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) scoring systems are the two models that are greatly used by the majority of ICUs to forecast the clinical consequence . The aim of our study was to assess the performance of APACHE II and SAPS II scoring methods in forecasting death among critically ill COPD patients admitted to the respiratory intensive care unit (RICU) at Assiut University Hospital.
| Materials and methods|| |
This prospective, descriptive, comparative research was performed from January 2018 to March 2019 and included 104 COPD patients who were admitted to the RICU with severe exacerbation requiring admission to the RICU (severe dyspnea that responds inadequately to initial emergency therapy, changes in mental status, persistent or worsening hypoxemia, persistent or worsening respiratory acidosis, the need for invasive mechanical ventilation, and/or hemodynamic instability). The diagnosis of COPD was based on the patient’s medical history obtained from the patient himself and/or the family of the patient, consistent physical findings, previous spirometry and/or evidence of hyperinflation on current or previous chest radiograph. Excluded from this study were COPD patients admitted to the ICU because of any other underlying problem such as those with acute cardiac situation, patients with respiratory failure due to other diseases along with COPD, patients who lasted less than 24 h in the ICU, and those who died before the completion of data collection. Our study was accepted by the Scientific Ethics Committee of Faculty of Medicine of Assiut University. Before participation, informed written consent to deal with the patient’s data for scientific purposes was obtained from the patients or persons in charge of them. We made sure to preserve patient privateness by not publishing identifying data. All patients involved have undergone full history with special stress on age, gender, special habits, and associated diseases. Information such as the patient’s need for mechanical ventilation as well as the duration of lodging in the ICU was entered. Routine laboratory variables were also registered. Patients were followed up until their outcome was determined. The outcome was decided according to the mortality within the ICU and recorded as survivors and nonsurvivors. Scores of APACHE II and SAPS II were calculated as illustrated in the previously published works ,.
Statistical Package for the Social Sciences (Version 20; IBM, Armonk, New York, USA) was used for analyzing the collected data. The nominal data was expressed in the form of frequency (percentage) and continuous data were expressed in the form of mean±SD or range. Student’s t-test was used to compare between continuous data while the nominal data was compared by χ2-test. Each scoring system was assessed for its discrimination (the ability of the scoring system to differentiate patients who die in the ICU from those who survive) and calibration (the degree of compatibility between calculated expectation of death produced by the scoring system and the true mortality). The discriminatory power was assessed by calculating the area under curve (AUC) in the receiver operating characteristic (ROC) curve (when this area approximates 1.0, the system becomes more ideal whereas when this area is in the direction of about 0.5, system performance becomes unexpected and inaccurate).Calibration of the model was assessed by Lemeshow–Hosmer goodness-of-fit C-statistic and calibration curve. (Patients were ranked in order of probability of death and were divided into 10 groups of approximately equal number of observations; predicted and observed deaths in these groups were compared using Pearson’s statistics (c). The model with the least c and the highest P value shows the best agreement between the observed and the predicted number of deaths.) The calibration curve, also named calibration plot, intends to provide complementary information. (If the model calibrates well, there will not be a substantial deviation from the 45° line of perfect fit or bisector. On the contrary, miscalibration of the model will be a function of expected probability.) To calculate the standardized mortality ratio (SMR), the observed mortality was divided by the predicted mortality. (If the SMR is equal to 1, then this means the number of observed deaths equals that of expected cases. If higher than 1, then there is a higher number of deaths than is expected.) The overall performance was finally evaluated by Brier score in order that estimating the predictive accuracy of the scoring system. It measures the average squared difference between the forecasted probabilities of consequences. A lower score represents a higher precision ,,.
| Results|| |
This study enrolled 104 patients with acute exacerbation of COPD that required admission to the RICU. Based on the outcome of the study population, 36 (34.6%) patients were non-survivors while 68 (65.4%) patients were survivors ([Figure 1]). [Table 1] shows baseline data of the studied patients based on the outcome. These data include age, sex, smoking, associated diseases, exposure to mechanical ventilation, duration of ICU stay, APACHE II score, and SAPS II score. The mean age of survivors was 62.67±10.61 years, while the mean age of nonsurvivors was 63.87±8.75 years. Majority of the studied patients were men. The proportion of smoking and comorbidities is higher in nonsurvivors but not statistically significant. The percentage of mechanically ventilated patients among the nonsurvivor group was significantly higher than those among survivors (80.6 vs 53%; P=0.03). It was noticed that the duration of ICU stay was significantly higher in non-survivors in comparison with survivors (14.36±5.94 vs 11.22±5.71 days; P=0.04). Both APACHE II and SAPS II scores were significantly higher in non-survivors (APACHE II: 24.61±6.96 vs 17.22±5.91; P<0.001 and SAPS II: 50.44±12.77 vs 39.26±9.06; P<0.001). Further illustration is shown in [Figure 2] for both APACHE II and SAPS II scores between survivors and nonsurvivors. Regarding the diagnostic accuracy of the severity scoring models used in our study, it can be explored from [Table 2] and [Figure 3] where at a cutoff greater than 20, APACHE II had a sensitivity of 72%and a specificity of 79% for prediction of mortality with an overall accuracy of 76.9%, while at a cutoff greater than 48, SAPS II had 61% sensitivity and 88% specificity for prediction of mortality with overall accuracy being 78.8%. [Table 3] and [Table 4] detail the Lemeshow–Hosmer goodness-of-fit statistics for APACHE II and SAPS II, respectively. It was noticed that the SMR for APACHE II was equal to 1, which denotes that the expected mortality by this score was equal to the observed mortality, while SMR for SAPS II equals 0.97 which denotes that the expected mortality by SAPS II score was more than the observed mortality and so, SAPS II overestimated in-ICU mortality but this was not statistically significant. Lemeshow–Hosmer goodness-of-fit statistics for SAPS II was 4.30. Both models calibrated well on formal goodness-of-fit testing, and had low C-statistic and low P values. Although APACHE II calibrated the best, insignificant difference was found between the two models ([Figure 4]). As regards the overall performance of both models based on Brier score, it was observed that APACHE II score had the least Brier score and reliability but had the highest resolution, so it is considered the best score in the present study for prediction of mortality ([Table 5]).
|Figure 2 Mean APACH II and SAPS II scores among survivors and nonsurvivors. APACH II, Acute Physiology and Chronic Health Evaluation II; SAPS II, Simplified Acute Physiology Score II.|
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|Table 2 Diagnostic accuracy of APACHE II and SAPS II scoring systems in predicting mortality among the studied patients|
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|Figure 3 Diagnostic accuracy of APACHE II and SAPS II scoring systems in predicting mortality among the studied patients. APACH II, Acute Physiology and Chronic Health Evaluation II; SAPS II, Simplified Acute Physiology Score II.|
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|Figure 4 Calibration curve of (a) APACHE II, it shows that if predicted mortality increases by 1, the observed mortality increases by 0.90 and (b) SAPS II, it shows that if the predicted mortality increases by 1, the observed mortality increases by 0.94. APACH II, Acute Physiology and Chronic Health Evaluation II; SAPS II, Simplified Acute Physiology Score II.|
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| Discussion|| |
The ICU in the chest department at Assiut University Hospital is the most important ICU for referral for respiratory diseases in Upper Egypt. It has 26 well-equipped beds and accommodates critically ill adult patients with acute or exacerbated respiratory failure caused by a disease that is primarily respiratory. To our knowledge, this is the first research that aims primarily to evaluate the performance of severity scoring models in predicting mortality among COPD patients admitted to our RICU. In this study, we evaluated the two most common models, APACHE II and SAPS II, in critically ill COPD patients who are the most commonly admitted cases to the RICU ,,. These two scoring models were compared in various previous studies that yielded somewhat contradictory results. However, we like to draw attention to the fact that we have not been able to obtain any previous studies comparing the performance of these models in predicting ICU mortality among patients with COPD in particular, but what we got is research on intensive care patients without allocating a specific disease or studies that have generally looked at predicting outcomes in critically ill COPD patients, so it may be difficult to compare our results with those of other studies.
This study enrolled 104 patients, based on the outcome of the study population; 36 (34.6%) patients were non-survivors while 68 (65.4%) patients were survivors. We found that both APACHE II and SAPS II scores were significantly higher in non-survivors than in survivors. Mohan et al. , Timmers et al. , and El-Shahat et al.  reported findings that are consistent with our results. Mean APACHE II and SAPS II scores among nonsurvivors were 24.61 and 50.44, respectively. In the previous reports, the mean scores among this group of patients were 23.17 and 51.55 in a study by Aminiahidashti et al. , 23.91 and 55.14 in a study by Faruq et al. , 31.5 and 63.9 in a study by Godinjak et al. , and 23.14 and 46.14 in a study by Fadaizadeh et al. . The findings of our study showed that 20 and 48 could be considered as reasonable cutoff points for APACHE II and SAPS II, respectively, which could predict survival or death. Previously recorded cutoff values for both models, respectively, were 27.5 and 50 in a study by Godinjak et al. , 13 and 44 in a study by Haq et al. , 13.5 and 27.5 in a study by Fadaizadeh et al. , and 14 and 26 in a study by Kandil et al. . To assess the discriminative power of APACHE II and SAPS II, ROC curve and AUC must be studied. In our study, these areas were 0.80 and 0.74 for APACHE II and SAPS II, respectively, which means that these two scoring systems are almost similar for AUC and have good discrimination power, although the discrimination was better slightly for APACHE II than for SAPS II. Previously reported area under the ROC curve of APACHE II and SAPS II included 0.83 and 0.87 in a study by Katsaragakis et al. , 0.78 and 0.81 in a study by Moreno et al. , 0.83 and 0.79 in a study by Arabi et al. , 0.81 and 0.84 in a study by Nouira et al. , and 0.88 and 0.87 in a study by Tan .The Lemeshow–Hosmer goodness-of-fit C statistics revealed good performance and good calibration for both models in our study. Although APACHE II calibrated the best, little difference was found between the two models. This was similar to the findings reported in studies by Naqvi et al.  and Fadaizadeh et al. . In contrast, calibration of the two models had some amount of lack of fit in studies by Aminiahidashti et al.  and Khwannimit and Geater . In this study, we observed that the SMR for APACHE II was equal to 1 and SMR for SAPS II was 0.97. This result indicates that APACHE II model predicted accurately the ICU mortality while SAPS II score slightly overestimated the mortality. Del Bufalo et al.  concluded that APACHE II score was a good predictor of ICU mortality and better than SAPS II, with a ratio between actual and predicted mortality being 86% for APACHE II and 83% for SAPS II. In a study by El-Shahat et al.  SMR with APACHE II was 90.3% and thus mortality was overestimated to a lesser extent. However, SMR with SAPS II was 119.6% and therefore it reduces the mortality to a higher extent. Regarding overall performance, we found that the Brier score of APACHE II and SAPS II was 0.47 and 0.53, respectively. In addition, the reliability of both models was 0.01 and 0.03 while the resolution was 0.23 and 0.20. In a study by Aminiahidashti et al.  the Brier score of APACHE II and SAPS II were 0.21 and 0.20, respectively. In addition, the reliability was 0.02 and 0.01 but this study did not comment on the resolution.
It was not strange to find different results among many studies regarding the performance of APACHE II and SAPS II. On the contrary, it was expected, perhaps for several reasons, including, first, varying quality of the ICUs across the world; second, the number of cases enrolled in the studies and their diagnosis; third, the difference in approach used to scoring the Glasgow coma scale in sedated patients; and fourth, the differences in the treatment received by the patients during the time between the hospital admission and their admission to the ICU or what is called admission time delay.
What we consider a limitation in our study is that we did not take into account the quality of care and type of treatment received by the patient during time before ICU admission. However, by looking at the results of our study, we can conclude that, first, APACHE II and SAPS II have nearly similar value in predicting mortality among COPD patients but with some preference for APACHE; and second, both models have good discrimination and good calibration.
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Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]