|Year : 2018 | Volume
| Issue : 2 | Page : 208-217
Validity of three scoring systems in assessing the severity and outcome in Al-Abbassia Chest Hospital Respiratory Intensive Care Unit patients
Taher Abd El-Hamid El-Naggar1, Riham H Raafat1, Safaa A Mohamed2
1 Department of Chest Diseases, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Al-Abbassia Chest Hospital, Cairo, Egypt
|Date of Submission||29-Aug-2017|
|Date of Acceptance||15-Sep-2017|
|Date of Web Publication||23-May-2018|
Safaa A Mohamed
BSc of Medicine and General Surgery, 18 El-Haram Street, Giza, Cairo, 12574
Source of Support: None, Conflict of Interest: None
Background ICU scoring systems allowed an assessment of the severity of disease and death prediction. As ICU populations, investigations and management were changed, scoring systems should be updated.
Aim The aim of this study was to evaluate three scoring systems in predicting outcome in Al-Abbassia Chest Hospital Respiratory ICU patients in 6 months.
Patients and methods It was conducted on newly admitted cases in Al-Abbassia Respiratory ICU from July 2016 till January 2017. All patients were evaluated on admission and after 48 h by Acute Physiology and Chronic Health Evaluation IV (APACHE IV), Sequential Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score II (SAPS II).
Results APACHE IV and SAPS II scores were significantly higher between dead than alive patients on admission and after 48 h, but were not able to predict death in ICU. SOFA score was insignificantly higher on admission and after 48 h between nonsurvivors. None of the three scores could predict the length of stay in ICU.
Conclusion APACHE IV and SAPS II scores were better than SOFA score as they were significantly higher between nonsurvivors but not to the extent to predict mortality or length of stay.
Keywords: Acute Physiology and Chronic Health Evaluation IV, critical illness, Sequential Organ Failure Assessment, Simplified Acute Physiology Score II
|How to cite this article:|
Abd El-Hamid El-Naggar T, Raafat RH, Mohamed SA. Validity of three scoring systems in assessing the severity and outcome in Al-Abbassia Chest Hospital Respiratory Intensive Care Unit patients. Egypt J Bronchol 2018;12:208-17
|How to cite this URL:|
Abd El-Hamid El-Naggar T, Raafat RH, Mohamed SA. Validity of three scoring systems in assessing the severity and outcome in Al-Abbassia Chest Hospital Respiratory Intensive Care Unit patients. Egypt J Bronchol [serial online] 2018 [cited 2018 Aug 14];12:208-17. Available from: http://www.ejbronchology.eg.net/text.asp?2018/12/2/208/233051
| Introduction|| |
Critical illness is any disease which results in physiological instability ending with disability or death in hours . Assessment of the illness severity is essential for ICU death prediction . ICU patients have different diseases . Variable factors could increase death including age, severity of the disease, comorbidities, for example, malignancy . ICU scoring systems derive a numerical value. They quantify the severity of illness . Classification presented by Le Gall  assumes that most scores are calculated on admission, for example, Acute Physiology and Chronic Health Evaluation (APACHE), Simplified Acute Physiology Score (SAPS). Others are repetitive, for example, Sequential Organ Failure Assessment (SOFA).
The APACHE score is the most applied score . The APACHE IV could predict mortality and stay in ICUs depending on several factors . APACHE IV predicts ICU death more than APACHE III . SOFA score on ICU admission is a good prognosis predictor . The SAPS II was described in 1993 by Jean-Roger Le Gall et al.  based on the European-North American Study (ENAS) database 17. It was developedin a large sample of 110 hospitals in Europe and 27 hospitals in North America. It is a favorable discriminator for admission to ICU .
| Patients and methods|| |
This study was done on newly admitted cases in Al-Abbassia Respiratory ICU (RICU) during 6 months from July 2016 till January 2017. Three hundred and fifty patients were admitted to RICU. After excluding admissions due to nonrespiratory diseases, patients who died within the first 48 h, and postarrest new admissions who did not regain their conscious, only 130 patients diagnosed as Chronic obstructive pulmonarydisease (COPD) exacerbations, asthma exacerbations, pneumonia, tuberculosis (TB), pulmonary embolism, obese hypoventilation, empyema, and pneumothorax were studied.
Patients were subjected to full history, examination, chest radiography, routine laboratory tests including complete blood picture, bleeding profile, liver function, kidney functions, and random blood glucose level, sputum examination for acid fast bacilli, and sputum culture and sensitivity.
All patients were evaluated on admission and after 48 h by using APACHE IV, SAPS II, and SOFA scores to evaluate these scores regarding prediction of length of stay and mortality rate in the RICU.
For APACHE IV score, data were entered including the following:
- Age, temperature, vital signs, mechanical ventilation, FiO2, PaO2, PaCO2, arterial pH, random blood sugar.
- Serum Na+, urine output, serum creatinine, blood urea, serum albumin, total bilirubin, hematocrit, white blood cell.
- Coma scale: eyes, verbal, motor.
- Chronic health conditions including chronic renal failure, hemodialysis, AIDS.
For SAPS II score, the data required were age, vital signs, mechanical ventilation or CPAP, PaO2, FiO2, urine output, BUN, NA, K, HCO3, bilirubin, white blood cell, and comorbidities, for example, hematologic malignancy.
Mortality prediction percentage was calculated using this equation:
For SOFA score, the data required were FiO2, PaO2, mechanical ventilation, platelets, bilirubin, Glasgow coma scale, mean arterial blood pressure, vasopressors, serum creatinine, and urine output.
The data were coded, tabulated, and statistically analyzed using IBM SPSS, version 22.0 (SPSS Inc., Chicago, Illinois, USA).
Descriptive statistics were done for quantitative data as minimum and maximum range with mean±SD for quantitative normally distributed data, but it was done for qualitative one as number and percentage.
Inferential analyses were done for quantitative variables using independent t-test in cases of two independent groups with normally distributed data. In qualitative data, inferential analyses for independent variables were done using χ2-test for differences between proportions and Fisher’s exact test for variables with small expected numbers. Correlations were done using Pearson’s correlation for numerical normally distributed data, and using Spearman’s ρ test for qualitative data. Receiver operating characteristic curve was used for evaluating different scores to differentiate between groups. Linear regression model was used to get independent factors affecting certain conditions. A P value less than 0.050 is significant, otherwise it is nonsignificant.
Diagnostic characteristics were calculated as follows:
Results were then tabulated and statistically analyzed using SPSS.
| Results|| |
The age group of the patients ranged from 15 to 83 years old. Ninety-two of them were men and 38 were women. Mortality rate among the studied cases was 52% (75% men and 25% women). Thirty-nine of the patients were diagnosed as COPD, 59 patients of pneumonia, 15 patients of TB, five were of interstitial lung disease, and four were suffering from bronchial asthma ([Table 1] and [Figure 1]).
|Table 1 Demographic characteristics and comorbidities of the studied cases (N=130)|
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APACHE IV, SOFA, and SAPS II scores were applied to all the patients on admission showing a mean score of 76.6, 4.8, and 37.7, respectively. After 48 h, scores were reapplied again. The mean scores were 62.8, 4.8, and 33.3, respectively. The mortality rate among the studied cases was 52% ([Table 2],[Table 3],[Table 4] and [Figure 2]).
|Table 3 Clinical scores 48 h after admission among the studied cases (N=130)|
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There was no significant statistical difference between dead and alive patients regarding age, sex, smoking status, addiction, comorbidities (diabetes mellitus, hypertension, ischemic heart disease, HIV, hepatitis C virus, and outcome of the patients ([Table 5]).
|Table 5 Comparison between dead and alive cases regarding demographic characteristics and comorbidities|
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No significant statistical difference was observed between dead and alive patients regarding their diagnosis. 29.4% of COPD patients, 48.5% of pneumonia patients, and 8.8% of TB patients did not survive. APACHE IV and SAPS II scores were significantly higher between nonsurvivors than survivors on admission and after 48 h, but could not predict death among studied cases. P values of APACHE IV and SAPS II on admission were 0.008 and 0.001, respectively. Area under the curve (AUC) were 0.62 and 0.66, respectively. After 48 h P values of both of them were 0.001. AUC were 0.76 and 0.82, respectively. SOFA score showed nonsignificant statistical difference between dead and alive patients on admission and after 48 h. AUC on admission was 0.54 and after 48 h it was 0.64 ([Table 6],[Table 7],[Table 8]).
|Table 7 Comparison between dead and alive cases regarding clinical scores at admission among the studied cases|
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|Table 8 Comparison between dead and alive cases regarding clinical scores 48 h after admission among the studied cases|
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APACHE IV score on admission and after 48 h showed negative correlation with stay at RICU ([Table 9] and [Table 10] and [Figure 3] and [Figure 4]). On admission, different scores showed nonsignificant differences between dead and alive COPD cases. After 48 h APACHE IV and SAPS II showed significant difference between alive and dead cases, but still could not predict mortality after 48 h; P values were 0.024 and 0.001 for APACHE IV and SAPS II score ([Table 11]). Regarding pneumonia, only SAPS II showed significant increase on admission (P=0.029). But after 48 h APACHE IV and SAPS II showed significant increase (P=0.001 of APACHE IV and SAPS II) among dead cases. None of them could predict mortality ([Table 12]). Different scores showed nonsignificant correlation between dead and alive TB cases and could not predict mortality ([Table 13]). Different scores had significant models for length of stay among COPD, pneumonia, and TB cases but could not predict length of stay ([Table 14],[Table 15],[Table 16],[Table 17]).
|Table 10 Diagnostic performance of scores predicting death among the studied cases|
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|Figure 3 Correlation between length of stay and admission APACHE score. APACHE, Acute Physiology and Chronic Health Evaluation.|
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|Figure 4 Correlation between length of stay and admission APACHE–SAPS score. APACHE, Acute Physiology and Chronic Health Evaluation; SAPS, acute physiology score.|
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|Table 11 Diagnostic performance of scores predicting death among chronic obstructive pulmonary disease cases|
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|Table 12 Diagnostic performance of scores predicting death among pneumonia cases|
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|Table 13 Diagnostic performance of scores predicting death among tuberculosis cases|
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|Table 14 Regression models of scores in predicting length of stay among the studied cases|
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|Table 15 Regression models for scores in predicting length of stay among chronic obstructive pulmonary disease cases|
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|Table 16 Regression models for scores in predicting length of stay among pneumonia cases|
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|Table 17 Regression models for scores in predicting length of stay among tuberculosis cases|
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| Discussion|| |
This prospective cohort study was conducted in the ICU at Al-Abbassia Chest Hospital. Three hundred and fifty patients were admitted between June 2016 and January 2017. Only 130 patients were included in the study. The patients’ age group ranged from 15 to 83 years old. Ninety-two of them were men and 38 were females. The mortality rate among studied cases was 52% (75% men and 25% women). Thirty-nine of the patients were diagnosed as COPD, 59 patients had pneumonia, 15 patients had TB, five were having interstitial lung disease and four were having bronchial asthma.
APACHE IV, SOFA and SAPS II score were applied to all the patients on admission revealing a mean score of 76.6, 4.8, and 37.7, respectively. After 48 h, the scores were reapplied again. Mean scores were 62.8, 4.8, and 33.3, respectively. The mortality rate among the studied cases was 52%.
The present study showed no significant difference between dead and alive cases regarding demographic characteristics and comorbidities including diabetes mellitus (11.5%), hypertension (12.3%), ischemic heart disease (11.5%), and HIV (3.1). The present study concluded limited number of elderly patients (only 32 patients). That may affect the result.
This was against Neilson et al.  in a study conducted in Singapore about mortality in the elderly in the ICU. It demonstrated that the ICU death increased with advancing age. It was conducted on elderly patients in the ICU .
Regarding diagnosis, our study showed no significant difference between dead and alive cases regarding diagnosis. Against that was a study on the 2596 patients confirmed that fewer patients died in the surgical group in ICU than in the nonsurgical group .
In the present study, died cases had significantly higher APACHE IV score and SAPS II score (on admission and after 48 h) than alive cases; SOFA score was nonsignificant among studied cases. This was correlated with a study done about predictive efficacy of APACHE IV in medical ICU, neurological ICU, and surgical ICU. It showed that APACHE IV can be used as a good predictor of mortality among all ICU patients . In a study about SOFA score in Amsterdam. It disagreed and illustrated that SOFA score on admission was good as the SAPS score in predicting death in ICUs. For a better performance, he suggested the combination of other scores on admission, for example, the APACHE IV score .
The current study demonstrated that there were negative correlations between length of stay and APACHE IV score and APACHE IV–SAPS score (on admission and after 48 h). Kramer and Zimmerman  agreed with that after studying early prediction of long stay in 831 ICUs. They claimed that patients with an ICU stay of at least 5 days had high SAPS and APACHE IV score on admission. Chattopadhyay and Chatterjee  conducted a study against that and provided that APACHE IV could not predict ICU stay in severe sepsis patients. But the results were affected by management of cases.
This study illustrated that only APACHE IV and SAPS II scores (on admission and after 48 h) had significant, but not valuable performance in predicting mortality rate. Parajuli et al.  studied the evaluation of APACHE II and APACHE IV to predict ICU mortality in tertiary level teaching hospital. He agreed and concluded that APACHE IV score increased significantly with increasing the mortality rate. APACHE IV was superior to APACHE II . In Iran a study was done in 2017 on 82 critically ill patients about comparing APACHE II and SAPS II scores in the ICU. It agreed with us. It showed that they were significant . A study was done in Korea including 1314 patients disagreed and showed that the APACHE IV overestimated mortality. It was done in surgical intensive care unit (SICU). Different categories of patient might led to that difference . Keegan et al.  disagreed with his study about APACHE III, APACHE IV, SAPS III, and mortality predictor model (MPM) 0 III and resuscitation. Different ICUs were included in his study. He demonstrated that the overall performance was best for APACHE IV. However, the single-center nature made that result not reliable .
Against that was a study done by Granholm et al.  about SAPS II and the SOFA scores in the ICU. He revealed that SAPS II was better than SOFA. SAPS II’s was less a predictor than other new severity scores. Desa et al.  disagreed and showed that SAPS II was a good discriminator but it over predicted death.
In this study, different scores had no significant valuable diagnostic performance in predicting death among COPD cases on admission but APACHE IV score and SAPS II score after 48 h are significant but not valuable performance. To our knowledge, there was no study done discussing the relationship between these scores and COPD patients in ICU, but a study done in 1996 on APACHE II score and COPD patients admitted in ward agreed with us .
Regarding pneumonia, this study showed that different scores had no significant valuable diagnostic performance in predicting death among pneumonia cases. SAPS II score, on admission and APACHE IV score, SAPS II score after 48 h were significant but not of valuable performance. This was correlated with the study done on patients with severe sepsis and septic shock in India. It showed that APACHE IV underestimated death while SAPS II had overestimated it. So, none of them could predict mortality . Another study was done on adult respiratory distress syndrome (ARDS) patients in Saudi Arabia agreed with the results. It showed that SAPS II and SOFA scores gave significantly different severity scores and mortality prediction in survivors compared with nonsurvivors among ICU patients with ARDS. However, their accuracy in predicting the actual mortality was limited .
This was against a study done in 2013 in Pakistan about APACHE II and APACHE IV in predicting death in acute lung injury and ARDS. Kamal et al.  claimed that APACHE IV was a good predictor in these patients. This difference might be due to more critical and limited numbers of patients enrolled in this study. Kamal et al.  enrolled 47 of mechanically ventilated ARDS patients.
In this study, it was illustrated that different scores had no significant valuable diagnostic performance in predicting death among TB cases. Koegelenberg et al.  study about severity scores in critically ill TB patients agreed with us. He demonstrated that the APACHE II score could not predict death in these patients. It was calculated 1 day after admission, so it is not a practical . Rollas et al.  study in 2015 disagreed after studying TB in the ICU on 16 patients. He confirmed that death increased in patients with high SOFA scores. Limited number of the studied patient might lead to different results .
This study showed that different scores had significant but not valuable predicting models for length of stay among the studied cases. Verburg et al.  agreed with that in his study. He claimed that no score could predict unexpectedly long stay in the ICU. Against that was Yamin et al.  he confirmed that the APACHE IV showed good prediction for stay and death in the ICU as an overall view but not with sepsis patients. Different categories of the studied patient might have affected the results .
Different scores had significant but not valuable predicting models for length of stay among COPD cases that was demonstrated in this study. Goel et al.  agreed with that in his study and suggested combination with other scores for better prediction. According to this study, different scores had significant but not valuable predicting models for length of stay among pneumonia cases. Chattopadhyay and Chatterjee  agreed with that after conducting a study in the USA. They used the data of 2006–2008 for that study. It confirmed that APACHE IV could not predict ICU stay in severe sepsis cases and underestimated it. That might be affected by policies of patient admission, accommodation, and management .
This study showed that different scores had significant but not valuable predicting models for length of stay among the TB cases. To our knowledge, there were no studies discussing that.
A study was done on 60 patients in Serbia on the assessment of scoring systems in the ICU. It confirmed that APACHE II, SAPS II scores on admission, and SOFA score after 1 week were significant predictors of consequences .
| Conclusion|| |
APACHE IV and SAPS II scores were significantly higher between nonsurvivors on admission and after 48 h of admission with COPD and pneumonia patients, but they could not predict neither mortality nor length of stay accurately.
APACHE IV and SAPS II scores were better than the SOFA score, which was nonsignificant among all studied cases on admission and after 48 h and could not predict mortality or length of stay among patients.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Robertson LC, Al-Haddad M. Recognize the critically ill patient. Anath Intensive Care Med
Saleh A, Ahmed M, Sultan I, Abdel-Lateif A. Comparison of the mortality prediction of different ICU scoring systems (APACHE II and III, SAPS II, and SOFA) in a single-center ICU subpopulation with acute respiratory distress syndrome. Egypt J Chest Dis Tuberc
Kao R, Priestap F, Donner A. To develop a regional ICU mortality prediction model during the first 24 h of ICU admission utilizing MODS and NEMS with six other independent variables from the Critical Care Information System (CCIS). J Intensive Care
Bouch DC, Thompson JP. Severity scoring systems in the critically ill. Contin Educ Anaesth Crit CarePain
Kelley MA, Cowen JS. Errors and bias in using predictive scoring systems. Crit Care Clin
Le Gall JR. The use of severity scores in the intensive care unit. Intensive Care Med
Chattopadhyay A, Chatterjee S. Predicting ICU length of stay using APACHE-IV in persons with severe sepsis − a pilot study. J Epidemiol Res
Yamin S, Vaswani AK, Afreedi DM. Predictive efficacy of APACHE IV at ICUs of CHK. Pak J Med
Jones A, Trzeciak S, Kline J. The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med
Rao MH, Marella P, Kath B. Assessment of severity and outcome of critical illness. Indian J Anaesth
Aegerter P, Boumendil A, Retbi A, Minvielle E, Dervaux B, Guidct B. SAPS II revisited. Intensive Care Med
Nielson M, Johanson M, Christian Fynbo C, Rasmussen B, Tonnesen E, Sogaard M et al.
Mortality in elderly patients admitted to the intensive care unit: a Danish 1 year cohort study. Crit Care Med
Keegan MT, Gajic O, Afessa B. Comparison of APACHE III, APACHE IV, SAPS 3, and MPM 0 III and Influence of Resuscitation Status on Model Performance. Chest
Minne L, Abu-Hanna A, de Jonge E. Evaluation of SOFA-based models for predicting mortality in the ICU: a systematic review. Crit Care
Kramer AA, Zimmerman JE. A predictive model for the early identification of patients at risk for a prolonged intensive care unit length of stay. BMC Med Inform Decis Mak
Parajuli BD, Shrestha GS, Pradhan B, Amatya R. Comparison of acute physiology and chronic health evaluation II and acute physiology and chronic health evaluation IV to predict intensive care unit mortality. Indian J Crit Care Med
Aminiahidashti H, Bozorgi F, Montazer SH, Baboli M. Comparison of APACHE II and SAPS II scoring systems in prediction of critically ill patient’s outcome. Emerg (Tehran)
Lee H, Shon YJ, Kim H, Paik H, Park HP. Validation of the APACHE IV model and its comparison with the APACHE II, SAPS 3, and Korean SAPS 3 models for the prediction of hospital mortality in a Korean surgical intensive care unit. Korean J Anesthesiol
Granholm A, Møller MH, Krag M, Perner A, Hjortrup BP. Predictive performance of the simplified acute physiology score (SAPS) II and the initial sequential organ failure assessment (SOFA) score in acutely ill intensive care patients: post-hoc analyses of the SUP-ICU inception cohort study. PloS One
. 2016; 10
Desa K, Peric M, Husedzinovic I, Sustic A, Korusic A, Karadza V et al.
Prognostic performance of the simplified acute physiology score II in major Croatian hospitals: a prospective multicenter study. Croat Med J
Goel A, Pincney R, Littenberg B. APACHE II predicts long-term survival in COPD patients admitted to a general medical ward. J Gen Intern Med
Dabhi A, Khedekar S, Vadivelan M. A prospective study of comparison of APACHE-IV&SAPS-II scoring systems and calculation of standardised mortality rate in severe sepsis and septic shock patients. J Clin Diagn Res
Kamal M, Khan AN, Ali G. A comparison of APACHE II and APACHE IV scoring systems in predicting outcome in patients with acute lung injury (ALI) and the adult respiratory distress syndrome (ARDS) in intensive care unit (ICU). RMJ
Koegelenberg CFN, Balkema CA, Jooste Y, Taljaard JJ, Irusen EM, Irusen EM. Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission. S Afr Med J
Rollas K, Kara A, OrtaçErsoy N, ÖzmenSüner K, Güllü M, Öcal S et al.
Acute tuberculosis in the intensive care unit. Turk J Med Sci
Verburg I, Atashi A, Eslami S, Holman R, Abu-Hanna A, de Jonge E et al.
Which models can I use to predict adult ICU length of stay? A systematic review. Crit Care Med
Sekulic AD, Trpkovic SV, Pavlovic AP, Marinkovic OM, Ilic AN. Scoring systems in assessing survival of critically ill ICU patients. Med Sci Monit
[Figure 1], [Figure 2], [Figure 3], [Figure 4]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8], [Table 9], [Table 10], [Table 11], [Table 12], [Table 13], [Table 14], [Table 15], [Table 16], [Table 17]