ORIGINAL ARTICLE
Year : 2017  |  Volume : 11  |  Issue : 3  |  Page : 203-208

Pattern of antiendothelial cell antibodies in patients with chronic obstructive pulmonary disease


1 Department of Chest, Faculty of Medicine, Beni-Sueif University, Egypt
2 Department of Chest, Beni-Sueif University, Egypt
3 Doctor at Suez Canal Institute, Egypt

Correspondence Address:
Abeer Salah Eldin Mohamed
Department of Chest Diseases and Tuberculosis, Chest Department Faculty of Medicine, Beni-Sueif University; Elfayoum Sheik Hamza Street Elhadka in front of Mekka Hospital
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-8426.203801

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Background Autoimmune mechanisms have been recently recognized as being partly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Circulating autoantibodies have been detected in patients with COPD. Objectives The aim of this study was to estimate the level of antiendothelial cell antibodies (AECA) in COPD patients in the various GOLD stages. Patients and methods A comparative study assessed the level of AECA in three groups. COPD patients without cor pulmonale (18), with cor pulmonale (12), and the control group (10), from Beni-Suef University Hospital. Each group underwent background questionnaires and BMI measures. Enzyme-linked immunosorbent assay was used to measure the level of AECA in serum (ng/ml). Right ventricular systolic pressure (mm Hg) was measured in COPD patients with cor pulmonale. Results The studied groups consisted of male patients (age: 50–80 years). BMI was significantly lower (20.36) in the COPD group with cor pulmonale. Spirometry forced expiratory volume and forced expiratory volume/forced vital capacity ratios showed significantly lower levels among the COPD patients without cor pulmonale. AECA showed a lower level in the control group (26.25) compared with the COPD without cor pulmonale (57.87) and much lowered when compared to cor pulmonale group (71.47). The level of AECD was higher in the patients in third (74.78) and fourth stages (79.10) compared with those in the second stage (58.75). Conclusion There is a much higher level of AECA in COPD patients with cor pulmonale and in advanced stages in comparison with patients without cor pulmonale and at early stages, and a significant positive correlation was found between AECA levels and right ventricular systolic pressure.


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