ORIGINAL ARTICLE
Year : 2017  |  Volume : 11  |  Issue : 1  |  Page : 23-28

Single-breath diffusion capacity of the lung for carbon monoxide in chronic obstructive pulmonary disease


1 Department of Chest Medicine, Faculty of Medicine, Helwan University, Helwan, Egypt
2 Department of Chest Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Correspondence Address:
Waleed M El-Sorougi
27 Omar Bakeer Street, Saint Fatima Sq., Heliopolis, Cairo 11361
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-8426.199002

Rights and Permissions

Background Chronic obstructive pulmonary disease (COPD) is defined by progressive, irreversible airflow limitation and an inflammatory response of the lungs, usually to cigarette smoke. However, COPD is a heterogenous disease in terms of clinical, physiological, and pathological presentation. The pathological hallmarks of COPD are inflammation of the small airways (bronchiolitis) and destruction of lung parenchyma (emphysema). The functional consequence of these abnormalities is airflow limitation. Aim of work The aim of the study was to measure diffusion capacity in different stages of COPD. Patients and methods Sixty outpatients with COPD with mild to very severe obstruction were included in the study. Results There was a statistically significant negative (inverse) correlation between TLCO%, TLCO/VA, PCO2, and HCO3 and there was a statistically significant positive (direct) correlation between TLCO%, TLCO/VA, PO2, and arterial oxygen saturation. There was a statistically significant positive (direct) correlation between FVC%, FEV1%, FEF25%, FEF50%, FEF75%, TLCO%, and TLCO/VA. Conclusion Reduced diffusion capacity of the lung for carbon monoxide plus airflow obstruction together identifies a group of individuals with significantly worse lung function.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed881    
    Printed17    
    Emailed0    
    PDF Downloaded97    
    Comments [Add]    

Recommend this journal