PULMONARY CRITICAL CARE
Year : 2015  |  Volume : 9  |  Issue : 3  |  Page : 231-237

Risk factors for hospital mortality among mechanically ventilated patients in respiratory ICU


Respiratory Intensive Care Unit (RICU), Chest Department, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt

Correspondence Address:
Hassan Bayoumi
Respiratory Intensive Care Unit (RICU), Chest Department, Faculty of Medicine, Assiut University Hospital, Assiut, 71111
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-8426.165895

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Background: The possible factors affecting hospital mortality among mechanically ventilated patients in respiratory ICU is still not fully studied. Objective: The aim of this study was to identify the predictors of hospital mortality among mechanically ventilated patients in respiratory ICU. Patients and methods: In a prospective descriptive study, all eligible patients of Assiut Chest Department who were mechanically ventilated for more than 1 day (247 patients) during the period from April 2010 to March 2012 were included in this study. Different clinical and laboratory variables were recorded at the time of admission and followed until hospital discharge and were compared between survivors (146 patients) and nonsurvivors (101 patients). Results: A total of 247 patients were included in the study. The mean age was 57.6 ± 13.3 years. Male patients represented 65.6% of the study cohort. The hospital mortality was 40.9%. On multivariate analysis, risk factors for hospital mortality were as follows: patients diagnosed with adult respiratory distress syndrome, interstitial lung diseases, and pulmonary embolism [odds ratio (OR) = 14.2 95% confidence interval (CI), P = 0.031]; hospital complications (OR = 9.17 95% CI, P = 0.000); reintubation (OR = 8.56 95% CI, P = 0.000); use of sedatives for 24 h or more (OR = 3.72 95% CI, P = 0.04); and comorbidity burden (OR = 2.36 95% CI, P = 0.006). Conclusion: The major independent risk factor for hospital mortality was patients diagnosed with adult respiratory distress syndrome, interstitial lung diseases, and pulmonary embolism. In addition, patients suffering from more comorbidities or hospital complications and patients requiring longer use of sedation (≥24 h) should be monitored closely in ICU because of their high risk for hospital nonsurvival.


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