ORIGINAL ARTICLE
Year : 2014  |  Volume : 8  |  Issue : 1  |  Page : 23-31

Pulmonary hypertension in idiopathic pulmonary fibrosis


1 Department of Chest Diseases, Assiut University, Faculty of Medicine, Minia University, Minia, Egypt
2 Department of Chest Diseases, Faculty of Medicine, Minia University, Minia, Egypt
3 Department of Cardiology, Faculty of Medicine, Minia University, Minia, Egypt
4 Department of Radiology, Faculty of Medicine, Minia University, Minia, Egypt

Correspondence Address:
Azza Farag Said El-Tooney
MD, Department of Chest Diseases, Faculty of Medicine, Minia University, 6111 Minia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1687-8426.137348

Rights and Permissions

Background Pulmonary hypertension (PH) is a common finding in patients with idiopathic pulmonary fibrosis (IPF) and is associated with increased morbidity and mortality. AimThis study was designed to detect the prevalence of PH in patients with IPF and to determine the correlation between pulmonary function test (PFT) parameters, radiological and echocardiographic findings, and PH among these patients. In addition, the effect of therapy for 1 month (long-term oxygen therapy ± drugs) on PH was evaluated. Patients and methods PFTs, the composite physiologic index, multidetector chest computed tomography, and echocardiography were performed on 60 IPF patients (10 men and 50 women, mean age 51 years). Fifteen healthy age-matched and sex-matched volunteers were also studied as a control group. Results PH was present in 46 (76.6%) patients of IPF. There was a high negative correlation between parameters of PFTs and composite physiologic index and the mean pulmonary arterial pressure (mPAP). In contrast, there was a significant positive correlation between mPAP and main pulmonary artery diameter on computed tomography. There was also a positive correlation between echocardiographic findings and mPAP. There was no significant improvement of PH between those patients treated with drugs and oxygen and those on oxygen therapy alone. Conclusion PH is common in patients with IPF. There is an inverse relationship between lung function measures and PH and a direct one with radiological and echocardiographic findings. The short-term use of oxygen therapy with or without drugs had no effect on PH in patients with IPF.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1191    
    Printed40    
    Emailed0    
    PDF Downloaded127    
    Comments [Add]    

Recommend this journal